There are various reasons why wp-cron does not work, one of the most common ones being a misconfigured network or firewall.
However, due to the way wp-cron works, anything that prevents WordPress opening a http connection to itself will cause wp-cron to fail. In my case I had a .htaccess password set on the development site to prevent crawlers from indexing it.
A quick test to see if WordPress will be able to access wp-cron.php is to use wget from the command line of your server:
wget http://www.example.com/
If this fails you will at least have a clue as to why it failed. It would be great if WordPress could log the failure rather than remaining silent (even with WP_DEBUG enabled). This was discussed in http://core.trac.wordpress.org/ticket/11831.
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